GLP-1 Drugs During Pregnancy: What Current Guidance Says
GLP-1 drug labels generally recommend discontinuing use before a planned pregnancy. Here's what the labeling says and why.
By the GLP Semaglutide editorial team · Last updated August 1, 2025
Current FDA labeling for GLP-1 drugs generally recommends discontinuing the medication before a planned pregnancy, with specific timing that varies by drug — Wegovy's label, for example, recommends stopping at least two months before a planned pregnancy given how long semaglutide stays in the body.
Why the caution
Data on GLP-1 drug use during human pregnancy remains limited, and animal studies have shown potential risks at certain exposure levels, which is the basis for the conservative labeling rather than confirmed evidence of harm in humans.
This requires a direct conversation
Anyone who is pregnant, planning a pregnancy, or breastfeeding while on a GLP-1 drug should talk to their prescriber promptly rather than stop or continue the medication based on general information like this article.
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