How GLP-1 Pens Are Stored and Transported: A Cold-Chain Guide
Most GLP-1 pens need refrigeration before first use and have a limited room-temperature window afterward. Getting this wrong can affect the drug's stability.
By the GLP Semaglutide editorial team · Last updated March 5, 2026
Unopened GLP-1 pens generally require refrigeration (typically 36–46°F / 2–8°C) until first use. After first use, most labels allow a defined room-temperature storage window, but that window and the maximum allowed temperature vary by specific drug and formulation.
Traveling with GLP-1 pens
Insulated travel cases designed for injectable medications can help maintain temperature during transit. Pens should never be frozen, and a pen that has been frozen should not be used even if it appears to thaw normally.
Check the specific insert
Storage rules differ enough between Ozempic, Wegovy, Mounjaro, and Zepbound that this article can only describe general patterns — the instructions for use that ship with your specific pen are the source to follow.
Primary sources